In our group, we perform multi-tracer PET imaging studies in cross-sectional and longitudinal study designs, in AD as well as in non-AD dementias. Patients are recruited from the Memory Clinic, Theme Aging, Karolinska University Hospital, Stockholm. Research participants include individuals from known families with genetic forms (autosomal dominant forms) of AD and other non-AD dementia.

Multi-tracer in vivo PET studies measuring different pathological markers including Aβ and tau deposition, astrocytosis, and cerebral glucose metabolism combined with cognitive tests, cerebrospinal fluid (CSF) biomarkers and MRI aim to answer following questions :

- What are the links between different regional pathological mechanisms leading to AD and non-AD dementias?
- Are the familial forms of AD a suitable model to better understand sporadic AD?
- Inflammation is playing a central role in AD. What is the relationship between the different proteinopathies and inflammatory processes?
- How can we develop new PET tracers for in vivo visualizing of important hallmarks of the neurodegenerative diseases?
- How can we bring molecular imaging into clinical practice and show its usefulness in selecting patients to certain therapies?